The reported issue is happening in at least two circumstances: Multiple people have reported VirtualBox having a variety of issues running VirtualBox and its Virtual Machines on macOS (Catalina and newer). Still Experiencing Problems? Symptoms of the VirtualBox macOS Security and Access Problem SOLUTION 3: Clean Re-install of VirtualBox.SOLUTION 2: Modify VirtualBox Permissions.SOLUTION 1: Allow Identified Apps to Access the System.Symptoms of the VirtualBox macOS Security and Access Problems Carleton Research Studies Seeking Participants.